NAD+ and Cellular Ageing – The Key to Youthful Vitality
- Saira Rehman
- Apr 22
- 3 min read
Ageing is an inevitable part of life, but the way we age is not set in stone. Scientific research has revealed that cellular ageing – the gradual decline in our cells’ ability to function and regenerate – plays a central role in how we experience ageing physically and mentally. One of the most promising discoveries in longevity science is the molecule Nicotinamide Adenine Dinucleotide (NAD+), a coenzyme crucial for cellular health and energy production. At Wellness By Resolve, our Anti-Ageing Protocol is designed to naturally support NAD+ levels, helping to slow biological ageing and enhance vitality.
What Happens When Our Cells Age?
Every cell in the body has a natural lifespan, during which it undergoes thousands of metabolic processes. Over time, exposure to oxidative stress, inflammation, and environmental toxins leads to cellular damage. Some key markers of cellular ageing include:
Mitochondrial Dysfunction – Mitochondria, the ‘powerhouses’ of the cell, become less efficient at producing energy.
DNA Damage & Telomere Shortening – The protective caps at the end of our chromosomes shrink, leading to cell deterioration.
Senescence (Zombie Cells) – Some cells stop dividing but don’t die, releasing harmful inflammatory signals.
This cellular breakdown manifests as fatigue, slower metabolism, cognitive decline, weakened immunity, joint stiffness, and visible signs of ageing like wrinkles and reduced skin elasticity (López-Otín et al., 2013).
The Role of NAD+ in Slowing Ageing
NAD+ is a vital molecule that fuels many essential cellular functions, including DNA repair, metabolism, and energy production. However, NAD+ levels decline significantly with age, leading to reduced cellular resilience. Research has shown that replenishing NAD+ can support longevity, improve brain function, and enhance physical energy (Verdin, 2015).
By boosting NAD+, we can:
Improve Mitochondrial Health – Increasing cellular energy, reducing fatigue, and enhancing endurance.
Support DNA Repair – Slowing the accumulation of cellular damage that accelerates ageing.
Reduce Inflammation – Lowering the risk of age-related diseases such as cardiovascular issues and neurodegeneration.
Enhance Cognitive Function – Supporting mental clarity, memory, and focus.
How Our Anti-Ageing Protocol Supports NAD+ Levels
At Wellness By Resolve, our Anti-Ageing Protocol combines therapies that naturally promote NAD+ production and enhance cellular rejuvenation:
Red Light Therapy (RLT) – Stimulates mitochondrial function and cellular repair, promoting NAD+ biosynthesis.
Hyperbaric Oxygen Therapy (HBOT) – Increases oxygen delivery to cells, supporting energy production and neuroprotection.
Infrared Sauna – Encourages detoxification and mitochondrial efficiency, reducing oxidative stress that depletes NAD+.
Lifestyle Strategies to Maintain NAD+ and Slow Ageing
Alongside targeted therapies, lifestyle choices play a critical role in preserving NAD+ levels and slowing biological ageing:
Optimised Sleep – Deep, restorative sleep allows the body to repair DNA and maintain healthy NAD+ production.
Nutrient-Rich Diet – Foods high in B vitamins (such as eggs, leafy greens, and fish) support NAD+ metabolism.
Intermittent Fasting – Has been shown to increase NAD+ and activate longevity genes (Cantó et al., 2009).
Exercise – High-intensity workouts boost NAD+ levels by stimulating mitochondrial renewal.
Supplementation – Compounds such as nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN)are precursors to NAD+ and have been linked to anti-ageing benefits (Yoshino et al., 2021).
Take Control of Your Ageing Process
Ageing isn’t just about genetics – it’s about how we care for our cells. By integrating NAD+-boosting therapies and a longevity-focused lifestyle, we can slow biological ageing, increase vitality, and maintain mental sharpness well into later life.
Experience the benefits of our Anti-Ageing Protocol and start turning back your body’s clock today.
Book your session now and invest in your long-term wellness.
References:
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013). The hallmarks of aging. Cell, 153(6), 1194-1217. https://doi.org/10.1016/j.cell.2013.05.039
Verdin, E. (2015). NAD+ in aging, metabolism, and neurodegeneration. Cell, 160(3), 484-495. https://doi.org/10.1016/j.cell.2015.02.008
Cantó, C., Gerhart-Hines, Z., Feige, J. N., Lagouge, M., Noriega, L., Milne, J. C., … Auwerx, J. (2009). AMPK regulates energy expenditure by modulating NAD+ metabolism. Cell Metabolism, 9(1), 91-102. https://doi.org/10.1016/j.cellmet.2009.06.011
Yoshino, J., Baur, J. A., & Imai, S. I. (2021). NAD+ intermediates: The biology and therapeutic potential of NMN and NR. Nature Medicine, 27(10), 1682-1692. https://doi.org/10.1038/s41591-021-01320-7
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